I've worn my Earth vegan shoes (3 pairs over the last 5 years) - and they are by far the most comfortable shoes I've ever owned. My Vibram 5 fingers are an experience in and of themselves, they simulate bare footwalking, so if you hike or go to lots of freestyle dance/rave/eccentric music festivals, I would reccomend stopping by a Sports store and trying on a pair.
Do it! Do it! But start out sllllllooooowww with running in them. Your feet aren't use to them yet, but when they are you'll be amazed how your ankles, knees and whole body feel. Wear them around while doing errands for the first week and let your feet relearn to land how they're meant to and then start a little running after. (this is what worked for me) And remember that the soles aren't as thick as you're use to, so when you step on something sharp you'll feel it. Good luck!!